Health Services Research
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Current Research Studies and Clinical Trials


ADAPTABLEFriends Having Lunch Together At A Restaurant

ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) is the first PCORnet interventional, randomized trial. ADAPTABLE will compare the effectiveness of two daily doses of aspirin widely used to prevent heart attacks and strokes in individuals living with heart disease. What we learn from the ADAPTABLE study will improve care and outcomes for patients with heart disease and could prevent as many as 88,800 deaths per year around the world.


The Louisiana Experiment Assessing Diabetes Outcomes (LEAD) is one of eight studies of the Natural Experiments Network, an observational diabetes study to assess the impact of reimbursable diabetes care coordination on clinical and patient-reported outcomes.


Program Description: WeighSmart is an investigator-initiated trial comparing two weight-loss interventions using smart scales with text message weigh-in reminders as an intervention to treat overweight and obesity in patients.


Program Description: INVESTED is a double-blind, randomized control clinical trial to assess whether a high-dose influenza vaccine compared with standard dose vaccine will reduce cardiopulmonary events in a high-risk cardiovascular patient population.


Program Description: RELIANCE is a pragmatic clinical trial intended to support evidence-based initiatives to reduce the risk of re-hospitalization or death in patients with chronic obstructive pulmonary disease (COPD). The trial will compare two drugs shown to reduce the risk of COPD exacerbations when compared to placebo.


Program Description: REACHnet is partnering with the YMCA to recruit participants using the Pragmatic Trial App Suite (PTAS) for the Diabetes Prevention Program (DPP). The DPP helps overweight adults at risk for type 2 diabetes reduce their risk for developing the disease by taking steps that will improve their overall health and well-being. Research by the National Institute of Health has shown that programs like the YMCA’s Diabetes Prevention Program can reduce the number of new cases of type 2 diabetes by 58%, and 71% in adults over the age of 60.

Bariatric Obesity Observational Studies

Program Description: The Bariatric Obesity Observational Studies are two studies on bariatric surgery outcomes and the relationship between antibiotic exposure and child growth. The studies are funded by PCORI at $9 million in direct costs over two years.